Systems and methods for drug therapy enhancement using expected pharmacodynamic models

A patient management system for monitoring a patient, the system comprising:

• an implantable device configured to measure data associated with at least one pharmacological effect of a drug on the patient and comprising a cardiac rhythm management (CRM) device including one or more pacemakers or one or more cardioverter defibrillators;
• a communication network;
• a host including a database module, an analysis module, and a delivery module, the database module configured to receive and store the measured data through the communication network, the analysis module configured to compare the measured data to an expected pharmacodynamic model and to predict and determine issues or failures of the implantable device using the measured data, the delivery module configured to manage the implantable device through the communication network using the measured data, wherein the expected pharmacodynamic model is selected based on at least one characteristic of the patient selected from the group consisting of age, race, national origin, gender, and genetic factors;
• a device configured to provide an alert using an outcome of the comparison of the measured data and the expected pharmacodynamic model;
• and
• interrogator/transceiver units each including an interrogator configured to receive the measured data from the implantable device wirelessly and a transceiver configured to send the received measured data to the host through the communication network.