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US 8,148,575 B2Granted
Radiofluorinated compounds and their preparation
AssigneeHammersmith Imanet Limited
InventorsErik Arstad, Matthias Eberhard Glaser
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Abstract
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
Claims7
Compound of formula (7)
- R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, R2 denotes a bio-molecule residue having at least one free amino function, and X denotes a physiological acceptable anion.
Dependencies are inferred from the claim text.