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US 8,148,554 B2Granted
Methods and compositions for use in treating cancer
AssigneeEisai R&D Management Co., Ltd.
InventorsBoris M. Seletsky, Melvin J. Yu, Wanjun Zheng
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Abstract
The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
Claims7
A compound having the formula:
A compound having the formula:
A compound having the formula:
A compound having the formula:
A compound having the formula:
A method of preparing:
- or a pharmaceutically acceptable salt thereof, the method comprising the steps of
- synthesizing a compound selected from the group consisting of
- and
- synthesizing B1939 or the pharmaceutically acceptable salt from the compound.
1 more element
A method of preparing:
- or a pharmaceutically acceptable salt thereof, the method comprising the steps of reacting
- under conditions to produce:
- reacting ER804029 under conditions to produce:
- reacting ER804030 under conditions to produce:
- reacting B2304 under conditions to produce:
- reacting B2303, B2303 under conditions to produce:
- reacting B2301 under conditions to produce:
- and
- reacting B1793 under conditions to produce B1939 or the pharmaceutically acceptable salt.
6 more elements
Dependencies are inferred from the claim text.