Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same

A rhodanine compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:

• wherein,
• R1 is one selected from the group consisting of:
• phenyl-C2-C6 alkoxy, phenyl-C1-C6 alkoxy substituted with halogen, phenyl-C1-C6 alkoxy substituted with nitro, phenyl-C1-C6 alkoxy substituted with halogen and nitro, phenyl-C1-C6 alkoxy substituted with C1-C6 alkyl, phenyl-C1-C6 alkoxy substituted with C1-C6 alkoxy, phenyl-C1-C6 alkoxy substituted with CF3, phenyl-C1-C6 alkoxy substituted with phenyl,
• nitro,
• phenoxy-C1-C6 alkoxy, phenoxy-C1-C6 alkoxy substituted with halogen, phenoxy-C1-C6 alkoxy substituted with cyano, phenoxy-C1-C6 alkoxy substituted with C1-C6 alkyl, phenoxy-C1-C6 alkoxy substituted with C1-C6 alkoxy, phenoxy-C1-C6 alkoxy substituted with 4-oxo-2-thioxo-thiazolidine,
• C1-C6 alkenyloxy,
• C1-C6 alkoxy substituted with benzhydryl, C1-C6 alkoxy substituted with benzoyl, C1-C6 alkoxy substituted with furan, C1-C6 alkoxy substituted with thiophene, C1-C6 alkoxy substituted with pyridine, C1-C6 alkoxy substituted with C1-C6 alkyl, C1-C6 alkoxy substituted with morpholine, C1-C6 alkoxy substituted with benzylpiperazine, C1-C6 alkoxy substituted with pyrrolidine, C1-C6 alkoxy substituted with tetrahydroisoquinoline, C1-C6 alkoxy substituted with imidazole, C1-C6 alkoxy substituted with carbazole, C1-C6 alkoxy substituted with acridine,
• oxy-C1-C6 alkoxy substituted with benzothiazole, oxy-C1-C6 alkoxy substituted with isoquinoline, oxy-C1-C6 alkoxy substituted with quinoline, oxy-C1-C6 alkoxy substituted with dibenzofuran,
• pyridine-oxy-C1-C6 alkoxy, pyridine-oxy-C1-C6 alkoxy substituted with C1-C6 alkyl, pyridine-oxy-C1-C6 alkoxy substituted with oxo,
• methylamino-C1-C6 alkoxy substituted with C1-C6 alkoxycarbonyl, methylamino-C1-C6 alkoxy substituted with acetyl, methylamino-C1-C6 alkoxy substituted with benzoyl, methylamino-C1-C6 alkoxy substituted with methanesulfonyl, methylamino-C1-C6 alkoxy substituted with benzenesulfonyl,
• methylaminocarbonylamino-C1-C6 alkoxy substituted with C1-C6 alkyl, methylaminocarbonylamino-C1-C6 alkoxy substituted with phenyl, methylaminocarbonylamino-C1-C6 alkoxy substituted with C1-C6 alkoxy,
• benzyl-NH—C(═S)-amino-C1-C6 alkoxy,
• phenoxy, phenoxy substituted with halogen, phenoxy substituted with cyano,
• morpholine, piperazine substituted with C1-C6 alkyl, piperazine substituted with benzyl,
• piperidine,
• pyrrolidine,
• C1-C6 alkylsulfonyl, and
• phenylsulfonyl substituted with C1-C6 alkyl or halogen;
• R2 is H, Br, or
• R3 is one selected from the group consisting of:
• H,
• Halogen,
• Hydroxyl,
• C1-C6 alkoxy substituted with halogen, C1-C6 alkoxy substituted with di(C1-C6 alkyl)amine, C1-C6 alkoxy substituted with piperidine, C1-C6 alkoxy substituted with benzylpiperazine, C1-C6 alkoxy substituted with morpholine, C1-C6 alkoxy substituted with tetrahydroisoquinoline, C1-C6 alkoxy substituted with phenoxazine, C1-C6 alkoxy substituted with indole, C1-C6 alkoxy substituted with imidazole, C1-C6 alkoxy substituted with carbazole, C1-C6 alkoxy substituted with pyridine,
• amino-C1-C6 alkoxy substituted with phenxoxy-C1-C6 alkylcarbonyl, amino-C1-C6 alkoxy substituted with benzoyl, amino-C1-C6 alkoxy substituted with acetyl, amino-C1-C6 alkoxy substituted with phenylaminocarbonyl, amino-C1-C6 alkoxy substituted with benzylaminocarbonyl, amino-C1-C6 alkoxy substituted with methanesulfonyl,
• phenyl-C1-C6 alkoxy, phenyl-C1-C6 alkoxy substituted with halogen,
• di(C1-C6 alkyl)amine, and
• phenyl substituted with di(C1-C6 alkyl)amine;
• R4 is one selected from the group consisting of:
• H, halo, C1-C6 alkoxy, phenyl-C1-C6 alkoxy, phenyl-C1-C6 alkoxy substituted with halogen, benzothiopene, benzofuran, phenyl substituted with C1-C6 alkoxy, phenyl substituted with di(C1-C6 alkyl)amine and benzodioxole;
• and
• R5 is H,
• where, apart from the definition, R3 and R4 together may form a phenyl ring or a halogen-substituted phenyl ring, or R4 and R5 together may form a phenyl ring, and wherein R2 to R5 are not all hydrogen at the same time.