Spiro substituted compounds as angiogenesis inhibitors

A compound of Formula II

• Wherein
• W and Z are each independently selected from O, or N—R;
• G is selected from C—R, or N;
• R, R1, R2 and R3 are each independently selected from H, halogen, halogeno-lower alkyl, lower alkyl, hydroxy, lower alkoxy;
• R4 and R5 are each independently selected from H, halogen, halogeno-lower alkyl, lower alkyl, cycloalkyl, hydroxy, lower alkoxy, lower alkoxyalkoxy, lower alkenyl, lower alkynyl, lower alkyl-OC(═O)—, ary-OC(═O)—, ary lower alkylenyl-OC(═O)—, lower alkyl-C(═O)—, ary-C(═O)—, ary lower alkylenyl-C(═O)—;
• R6 is H or F;
• b is selected from 1, 2 or 3;
• ring Q is selected from following groups:
• or a pharmaceutically acceptable salt thereof.