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US 8,148,523 B2Granted
Intermediates useful in preparing certain pyrrolotriazine compounds and a process for making the intermediates
AssigneeBristol-Myers Squibb Company
InventorBrian E. Fink
Life of this patent
Estimating the term…
Abstract
The invention relates to 4-chloro-2-iodopyrrolo[1,2-f][1,2,4]triazine, which is an intermediate useful in preparing 2,4-disubstituted pyrrolotriazine compounds, and a process for preparing said intermediate.
Claims5
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A process for preparing a compound I of the formula,
- or a pharmaceutically acceptable salt thereof, comprising
- reacting Compound A of the formula
- with benzoylisothiocyanate in a solvent to afford Compound B of the formula
- hydrolyzing Compound B in aqueous media, to afford Compound C of the formula
- cyclizing Compound C to afford Compound D of the formula
- reacting Compound D with n-pentylnitrite, followed by a halide source to afford Compound E of the formula
- treating Compound E with a chlorinating agent in the presence of a base to afford Compound I.
4 more elements
A process for preparing a compound I of the formula,
- or a pharmaceutically acceptable salt thereof, comprising
- reacting Compound A of the formula
- with benzoylisothiocyanate in a solvent to afford Compound B of the formula
- hydrolyzing Compound B in aqueous media, to afford Compound C of the formula
- cyclizing Compound C to afford Compound D of the formula
- reacting Compound D with n-pentylnitrite, followed by a halide source, which is diiodomethane, to afford Compound E of the formula
- treating Compound E with a chlorinating agent, which is phosphorous oxychloride, in the presence of a base to afford Compound I.
4 more elements
Dependencies are inferred from the claim text.