Back to results
US 8,148,492 B2Granted
Synthetic pulmonary surfactant peptides
AssigneeChiesi Farmaceutici S.p.A.
InventorsJan Johansson, Tore Curstedt, Bengt Robertson, Maurlzio Delcanale
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical compositions thereof and to a use thereof in the treatment or prophylaxis of RDS and other respiratory disorders.
Claims38
An isolated polypeptide comprising the sequence represented by formula (I)
- XΔLCRALIKRFNRYLTPQLVCRLVLRΦΣn
- (I;
- SEQ ID NO:
- 1)
- wherein
- X is an amino acid residue independently selected from the group consisting of C, A, G, K, R, D and E;
- Δ is an amino acid residue selected form the group consisting of W, L, nL and I;
- Φ is an amino acid residue independently selected from the group consisting of C, A, G, K, R, D and E
- Σn is an amino acid residue selected from the group consisting of S, G and A with a frequency represented by n
- n is an integer having a value of 0 or 1.
7 more elements
An isolated polypeptide comprising the sequence represented by formula (II)
- XΔLCRALIKRYNGKPQLVCRLVLRΦΣn
- (II;
- SEQ ID NO:
- 6)
- wherein
- X is an amino acid residue independently selected from the group consisting of C, A, G, K, R, D and E;
- Δ is an amino acid residue selected from the group consisting of W, L, nL and I;
- Φ is an amino acid residue independently selected from the group consisting of C, A, G, K, R, D and E
- Σn is an amino acid residue selected form the group consisting of S, G and A with a frequency represented by n
- n is an integer having a value of 0 or 1.
7 more elements
Dependencies are inferred from the claim text.