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US 8,148,407 B2Granted
Compounds derived from 5-thioxylose and their use in therapeutics
AssigneeLaboratories Fournier S.A.
InventorsVéronique Barberousse, Michel Bondoux, Didier Thomas, Vincent Peyrou
Life of this patent
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Abstract
The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.
Claims10
A compound selected from the group consisting of:
- a) compounds corresponding to formula I
- wherein
- the pentapyranosyl group is a free or acylated 5-thio-β-D-xylopyranosyl group;
- R is a hydrogen atom or a C2-C6 acyl group;
- R1 is a C1-C4 alkylsulfonyl group, a C2-C6 acyl group, a group CONR′R″ or a group
- wherein
- X is a single bond, an oxygen atom, a sulfoxy group, a group —CO— or a group —CHOH—;
- Ra is a hydrogen atom, a halogen, a hydroxyl group, a C1-C4 alkyl group, a trifluoromethyl group, a trifluoromethoxy group, a cyano group, a C1-C4 hydroxyalkyl group, a C2-C4 acyl group, a C1-C4 alkoxy group or a group NR′R″;
- wherein R′ and R″ independently are each a hydrogen atom or a C1-C4 alkyl group optionally substituted by an aromatic ring, or together with the nitrogen atom to which they are attached form a ring having 5 or 6 carbon atoms;
- Rb and Rc independently of one another are each a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a cyano group or a C1-C4 alkoxy group;
- and
- R2 is a hydrogen atom, a C1-C4 alkyl group or a halogen atom;
- b) acid addition salts of a);
- and
- c) active metabolites of b) and c).
12 more elements
Dependencies are inferred from the claim text.