AKT and P70 S6 kinase inhibitors

A compound of the formula:

• wherein:
• X is F, Cl, CF3, CN or H;
• Y is F, H or Cl;
• R1 and R2 are independently H, C1-C4 alkyl or CH2CH2OH;
• or R1 and R2 together with the nitrogen atom to which they are attached form a pyrrolidine ring optionally substituted with hydroxymethyl at the 2-position or hydroxy at the 3-position, or an azetidine ring substituted with hydroxy at the 3-position;
• R3 is H or OH;
• R6 is H;
• or R6 and R2 together with the nitrogen atom to which R2 is attached form a piperidine ring;
• R2 and R8 are independently H or CH3;
• or R7 and R1 together with the nitrogen atom to which R1 is attached form a pyrrolidine ring;
• W is CR4R5, NR10, C═O or C═CH—R9;
• R4 and R5 are independently H, CH3, or CH2CH3;
• R4 and R5 together with the carbon atom to which they are attached form a cyclopentane ring;
• or one of R4 or R5 is benzyl and the other is H;
• R9 is 2-thiazolyl, 4-pyridyl, 2-methyl-4-thiazolyl, 2-imidazolyl, 5-thiazolyl, or 4-imidazolyl;
• and
• R10 is H or C1-C3 alkyl;
• or a pharmaceutically acceptable salt thereof.