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US 8,148,375 B2Granted
(Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament
AssigneeSanofi-Aventis
InventorsElisabeth Defossa, Thomas Klabunde, Viktoria Dietrich, Siegfried Stengelin, Guido Haschke, Andreas Herling, Johanna Kuhlmann-Gottke, Stefan Bartoschek
Life of this patent
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Abstract
The invention relates to (cyclopropylphenyl) phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
Claims12
A compound of formula I
- wherein:
- R1, R2, R3, R4 and R5 are, independently, H, F, Cl, Br, CN, CF3, OH, OCF3, OCHF2, SCH3, SCF3, phenyl, O-phenyl, COOH, COO—(C1-C6)-alkyl, CO—(C1-C6)-alkyl, (C1-C6)-alkyl, O—(C1-C6)-alkyl, O-Bn, SO2—(C1-C4)-alkyl, SO3H, SO2NR9R10, NR9R10 or SO2—N-piperidinyl, wherein the alkyl and phenyl are optionally substituted one or more times by R12;
- R7 and R8 are, independently, H or (C1-C6)-alkyl;
- m is 0, 1, 2, 3 or 4;
- R6 is OH, F, Cl, Br, CN, OCH3, OCF3, CH3, CF3, (C1-C6)-alkyl or O—(C1-C6)-alkyl, wherein the alkyl is optionally substituted one or more times by OH, F, Cl, Br or CN;
- R9 and R10 are, independently, H, (C1-C6)-alkyl or phenyl, wherein the alkyl is optionally substituted one or more times by F, Cl or Br, and the phenyl is optionally substituted one or more times by R6;
- R11 is F, Cl, Br, CN, OH, O—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl or NR9R10;
- and
- R12 is F, Cl, Br, CN, OH, O—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, NR9R10, COOH, COO—(C1-C4)-alkyl, SCH3, SCF3, SO2—(C1-C4)-alkyl, SO3H or SO2NR9R10;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.