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US 8,148,364 B2Granted
Substituted bicyclic pyrimidone derivatives
AssigneesSanofi-Aventis, Mitsubishi Tanabe Pharma Corporation
InventorsNathalie Chereze, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
Life of this patent
Estimating the term…
Abstract
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, n, m, and o are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.
Claims10
A compound of formula (I) or a salt thereof:
- wherein:
- Y represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom;
- Z represents a bond, an oxygen atom, a nitrogen atom substituted by a hydrogen atom or a C1-3 alkyl group, a sulfur atom, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-2 perhalogenated alkyl group or an amino group;
- R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted by a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom;
- R2 represents a benzene ring or a naphthalene ring;
- the rings being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, C3-7 cycloalkyl group, a C3-7 cycloalkyl-C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group optionally substituted by a C3-5 cycloalkyl group, a C1-2 perhalogenated alkoxy group, a C1-6 alkylsulfonyl group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group, a C2-12 dialkylamino group, an acetoxy group or an aminosulfonyl group;
- R3 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom;
- R4 represents a hydrogen atom or a C1-6 alkyl group;
- R5 represents a hydrogen atom, a C1-6 alkyl group optionally substituted by 1 to 4 substituents selected from a halogen atom, a phenyl group, a hydroxyl group or a C1-6 alkoxy group;
- R6 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom;
- R7 represents a hydrogen atom or a C1-6 alkyl group;
- and
- n represents 0 to 3;
- m represents 0 to 1;
- o represents 0 to 2.
12 more elements
Dependencies are inferred from the claim text.