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US 8,148,328 B2Granted
Salicylanilides enhance oral delivery of therapeutic peptides
AssigneeThe Regents of the University of California
InventorsAlan M. Fogelman, Mohamad Navab
Life of this patent
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Abstract
This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significantly increases the bioavailability of that peptide. Methods of peptide delivery using such “delivery agents” and pharmaceutical formulations are provided.
Claims23
A method of mitigating one or more symptoms of atherosclerosis in a mammal, said method comprising:
- orally administering to said mammal an effective amount of a “D” or “L” peptide and niclosamide, wherein said peptide ranges in length from about 18 to about 50 amino acids and comprises an amino acid sequence selected from the group consisting of peptide D-W-F-K-A-F-Y-D-K-V-A-E-K-F-K-E-A-F (4F, SEQ ID NO:5), F-A-E-K-F-K-E-A-V-K-D-Y-F-A-K-F-W-D (retro 4F, SEQ ID NO:
- 104), D-W-L-K-A-F-Y-D-K-F-F-E-K-F-K-E-F-F (6F, SEQ ID NO:7), and F-F-E-K-F-K-E-F-F-K-D-Y-F-A-K-L-W-D (retro 6F, SEQ ID NO:537).
Dependencies are inferred from the claim text.