Regulation of gene expression by protein methylation
AssigneesThe Regents of the University of California, University of Southern California
InventorsMichael R. Stallcup, Dagang Chen, Heng Hong, Dana W. Aswad
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Abstract
The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.
Claims13
An isolated or recombinant polypeptide comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 2 and which polypeptide binds the C-terminal fragment of GRIP1.
An isolated or recombinant polypeptide comprising the amino acid sequence of SEQ ID NO:
- 3.
An isolated or recombinant polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.