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US 8,147,872 B2Granted
Pharmaceutical compositions of drugs and neutralized acidic polymers
AssigneeBend Reseach, Inc.
InventorsMarshall Crew, Dwayne T. Friesen, Rodney J. Ketner, Ravi M. Shanker, James B. West
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Abstract
Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.
Claims15
A process for forming a pharmaceutical composition, comprising
- (a) dissolving the following components in a common solvent to form a solution:
- (1) a low-solubility acid-sensitive drug;
- (2) an acidic polymer;
- and
- (3) sufficient base to neutralize said acidic polymer to form a neutralized acidic polymer having a degree of neutralization of at least 0.9;
- (b) atomizing said solution in the presence of a drying gas to form droplets ranging in size from 1 to 500 microns;
- and
- (c) removing said solvent so as to form solid particles of a solid amorphous dispersion comprising said drug and said neutralized acidic polymer.
5 more elements
Dependencies are inferred from the claim text.