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US 8,147,863 B2Granted
Polyarylates for drug delivery and tissue engineering
AssigneeRutgers, The State University of New Jersey
InventorsJoachim B. Kohn, Satish Pulapura, Arthur Schwarz, Raman Bahulekar
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Abstract
Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.
Claims16
A biocompatible resorbable polyarylate comprising a copolymer of strictly-alternating monomer units consisting of a a biocompatible dicarboxylic acid compound having the structure:
- HO—(C═O)—(CH2—)aO—[(CH2—)aCHR3—O—]m(CH2—)a—(C═O)—OH
- wherein a is from 1 to 3, inclusive, m is from 1 to 500,000, inclusive, R3 is hydrogen or a lower alkyl group containing from one to four carbon atoms, provided that m is not 1 when each a=1 and a biocompatible tyrosine-derived diphenol compound having the structure:
- wherein R1 is CH═CH or (CH2)n wherein n is from 0 to 18 inclusive;
- and R2 is selected from the group consisting of hydrogen and straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms.
1 more element
Dependencies are inferred from the claim text.