Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsGilad Ofek, Peter D. Kwong, Richard Wyatt, Min Tang
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Abstract
This invention relates to novel peptide immunogens that generate an immune response in mammals against HIV gp41, to pharmaceutical compositions that comprise such immunogens, and to methods of treating Immunodeficiency disease, especially HIV infection and AIDS, that employ such pharmaceutical compositions.
Claims7
An isolated peptide that comprises at least ten contiguous amino acids of the sequence EKNEQELLELDKWASLW (SEQ ID NO:
- 1) and that binds to monoclonal antibody 2F5, wherein (i) the isolated peptide is conformationally stabilized to provide a three dimensional structure that corresponds to that of SEQ ID NO:
- 1 when complexed with the 2F5 antibody, (ii) the isolated peptide comprises a face that does not bind to the 2F5 antibody, and (iii) the isolated peptide is associated with a lipid.
A method of generating a humoral immune response against a human immunodeficiency virus type 1 (HIV-1) gp41 envelope glycoprotein in a mammal, which method comprises (a) preparing a composition comprising the isolated peptide of claim and a pharmaceutically acceptable carrier, and (b) administering the composition to a mammal, whereupon a humoral immune response is generated against the HIV-1 gp41 envelope glycoprotein in the mammal.
Dependencies are inferred from the claim text.