Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins
AssigneeDyax Corp.
InventorsClive R. Wood, Daniel T. Dransfield, Laetitia Devy
Life of this patent
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Abstract
Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis.
Claims16
A method for treating osteotropic cancer arising from metastatic prostate cancer in a subject, the method comprising administering to said subject an effective amount of an antibody that specifically binds to a MMP-14 polypeptide comprising SEQ ID NO:
- 1, wherein the antibody inhibits the activity of MMP-14 and comprises a heavy chain immunoglobulin variable domain sequence and a light chain immunoglobulin variable domain, wherein the heavy chain immunoglobulin variable domain sequence comprises the heavy chain CDR1, CDR2 and CDR3 of SEQ ID NO:22 and the light chain immunoglobulin variable domain sequence comprises the CDR1, CDR2 and CDR3 of SEQ ID NO:
- 23, thereby treating the osteotropic cancer in the subject.
A method for reducing the development of osteolytic lesions arising from metastatic prostate cancer in a subject, the method comprising administering to said subject an effective amount of an antibody that specifically binds to a MMP-14 polypeptide comprising SEQ ID NO:
- 1, wherein the antibody inhibits the activity of MMP-14 and comprises a heavy chain immunoglobulin variable domain sequence and a light chain immunoglobulin variable domain sequence, wherein the heavy chain immunoglobulin variable domain sequence comprises the heavy chain CDR1, CDR2 and CDR3 of SEQ ID NO:22 and the light chain immunoglobulin variable domain sequence comprises the CDR1, CDR2 and CDR3 of SEQ ID NO:23, thereby reducing the development of said osteolytic lesions in the subject.
Dependencies are inferred from the claim text.