Binding domain-immunoglobulin fusion proteins

A single chain binding domain-immunoglobulin fusion protein that binds human CD37, comprising from N-terminus to C-terminus:

• (a) a human CD37-specific single chain Fv (scFv) binding domain polypeptide, wherein the scFv binding domain polypeptide comprises an immunoglobulin light chain variable region as set forth in amino acids 21-127 of SEQ ID NO:13 and an immunoglobulin heavy chain variable region as set forth in amino acids 144-259 of SEQ ID NO:13;
• (b) a human IgG1 hinge region polypeptide comprising amino acids 269-283 of SEQ ID NO:586;
• (c) an immunoglobulin heavy chain CH2 constant region polypeptide as set forth in amino acids 284-393 of SEQ ID NO:586-, and
• (d) an immunoglobulin heavy chain CH3 constant region polypeptide as set forth in amino acids 394-500 of SEQ ID NO:586.

A single chain binding domain-immunoglobulin fusion protein that binds human CD37, comprising from N-terminus to C-terminus:

• (a) a human CD37-specific single chain Fv (scFv) binding domain polypeptide, wherein the scFv binding domain polypeptide comprises a sequence comprising complementary determining regions of amino acids 44-54, 70-76, and 109-117 of an immunoglobulin light chain variable region as set forth in amino acids 21-127 of SEQ ID NO:13, fused via a linker polypeptide to a sequence comprising complementary determining regions of amino acids 174-178, 195-211, and 244-250 of an immunoglobulin heavy chain variable region as set forth in amino acids 144-259 of SEQ ID NO:13, wherein the linker polypeptide comprises amino acids 128-142 of SEQ ID NO:13,
• (b) a human IgG1 hinge region polypeptide comprising amino acids 269-283 of SEQ ID NO:586;
• (c) an immunoglobulin heavy chain CH2 constant region polypeptide as set forth in amino acids 284-393 of SEQ ID NO:586, and
• (d) an immunoglobulin heavy chain CH3 constant region polypeptide as set forth in amino acids 394-500 of SEQ ID NO:586.