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US 8,147,834 B2Granted
Anti-TGF-beta receptor II antibodies
AssigneeImClone LLC
InventorYan Wu
Life of this patent
Estimating the term…
Abstract
The present invention is directed to antibodies against human transforming growth factor beta receptor II (TGFβRII), pharmaceutical compositions comprising antibodies and methods of using the antibodies, alone or in combination, for example, for treating cancer and fibrosis.
Claims5
An isolated antibody that specifically binds to the extracellular domain of human TGFβ receptor II (TGFβRII) comprising a CDRH1 having the sequence GGSISNSYF (SEQ ID NO:
- 1), a CDRH2 having the sequence SFYYGEKTYYNPSLKS (SEQ ID NO:
- 2), a CDRH3 having the sequence GPTMIRGVIDS (SEQ ID NO:
- 3), a CDRL1 having the sequence RASQSVRSYLA (SEQ ID NO:
- 10), a CDRL2 having the sequence DASNRAT (SEQ ID NO:
- 11), and a CDRL3 having the sequence QQRSNWPPT (SEQ ID NO:
- 12).
3 more elements
Dependencies are inferred from the claim text.