Method and device for isolating a chemically and radiochemically cleaned 68Ga-radionuclide and for marking a marking precursor with the 68Ga-radionuclide
AssigneeJohannes Gutenberg-Universitat Mainz
InventorsFrank Roesch, Dmitry V. Filosofov, Konstantin Zhernosekov, Marc Jennewein
Life of this patent
Estimating the term…
Abstract
The invention relates to initial 68Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon 68Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and radio chemical manner. Subsequently, the 68Ga-radio nuclide is combined with a radio pharmaceutical substance by a marking precursor made of a ligand or a peptide or a protein which is cross-linked in a covalent manner to a ligand.
Claims26
Method for isolating a 68Ga radionuclide from a 68Ge/Ga generator eluate which contains 68Ga in ionic form, said method comprising feeding the 68Ge/Ga generator eluate directly into an exchanger and absorbing 68Ga quantitatively on the exchanger, and simultaneously chemically and radiochemically purifying the 68Ga and combining the 68Ga radionuclide with a labelling precursor comprising a ligand to form a radiopharmaceutical, wherein the exchanger is a cation exchanger and the cation exchanger is a highly acidic cation exchanger comprising a matrix from the group of polystyrene/divinylbenzene (DVB) resins, with a DVB concentration from 2 to over 20% in reference to cross-linked polymers of the resins and the matrix of the cation exchanger is loaded with 68Ga.
Method for extracting a 68Ga radionuclide from a 68Ge/Ga generator eluate which contains 68Ga in ionic form along with Ti, Fe (III) and Zn (II) contaminants, said method comprising
- feeding generator eluate into a cation exchanger comprising sulphonic acid groups, said cation exchanger absorbing 68Ga, Fe (III), Zn (II) and Ti onto the exchanger from the 68Ge/Ga generator eluate and removing the exchanger-eluate comprising the 68Ga fraction;
- eluting the Fe (III) and Zn (II) from the cation exchanger via a first acidic solution into a waste vessel;
- eluting the 68Ga from the cation exchanger via a second acidic solution into a labeling vessel;
- flushing with compressed air to collect 68Ga residues and feed them into the labeling vessel;
- forming a 68Ga-labelled radiopharmaceutical by labeling the purified 68Ga within the labeling vessel with a labeling precursor;
- filtering the 68Ga-labelled radiopharmaceutical through a sterile filter into a product vessel for use thereafter, and
- flushing residues of the Ti remaining on the cation exchanger into a waste vessel;
- wherein said method is performed in about 20 minutes.
Dependencies are inferred from the claim text.