Back to results
US 8,147,802 B2Granted
Chelator-functionalized nanoparticles
AssigneeGeneral Electric Company
InventorsZhebo Ding, Brian James Grimmond, Michael Luttrell, Slawomir Rubinsztajn, David Cheney deMoulpied, Margaret L. Blohm
Life of this patent
Estimating the term…
Abstract
Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also provided are methods of making such chelator-functionalized nanoparticles as well as imaging methods using the nanoparticles.
Claims10
A nanoparticle comprising:
- an MR-passive core having a coating comprising functionalized organosilane moieties and a plurality of linear chelators, wherein each of the plurality of linear chelators is attached to the passive core via an organosilane moiety through a single point of attachment;
- and
- a plurality of non-paramagnetic counterions, wherein each of the plurality of non-paramagnetic counterions is complexed with the linear chelator;
- and wherein the DH of the nanoparticle is less than 35 nm.
1 more element
Dependencies are inferred from the claim text.