Rapid-read gated amperometry
AssigneeBayer HealthCare LLC
InventorHuan-Ping Wu
Life of this patent
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Abstract
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Input signals including multiple duty cycles of sequential excitation pulses and relaxations are input to the sample. One or more signals output from the sample within 300 ms of the input of an excitation pulse may be correlated with the analyte concentration of the sample to improve the accuracy and/or precision of the analysis. Determining the analyte concentration of the sample from these rapidly measured output values may reduce analysis errors arising from the hematocrit effect, mediator background, and other error sources.
Claims45
A method, comprising:
- applying an input signal to a sample, where the input signal has at least 3 duty cycles within 10 seconds, and where each of the at least 3 duty cycles includes an excitation pulse and a relaxation;
- measuring an output signal responsive to a measurable species within 300 milliseconds of an excitation pulse of at least one duty cycle;
- and
- determining a concentration of an analyte in the sample in response to the measured output signal.
A method of reducing bias in a determined concentration of an analyte in a sample, comprising:
- applying an input signal to the sample, where the input signal has at least 3 duty cycles within 10 seconds, and where each of the at least 3 duty cycles comprises an excitation pulse and a relaxation;
- measuring an output signal responsive to a measurable species within 300 milliseconds of an excitation pulse of at least one of the at least 3 duty cycles;
- and
- determining a concentration of the analyte in the sample in response to the measured output signal.
Dependencies are inferred from the claim text.