US 8,147,540 B2 · Taxane coatings for implantable medical devices

Abstract

This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.

Claims17

Dependent claims

A method of delivering a taxane therapeutic agent to a body vessel of a patient comprising:

inserting a coated implantable device into the body vessel, wherein the coated implantable device comprises at least one surface having a coating comprising
the taxane therapeutic agent in a first taxane solid form characterized by a vibrational spectrum comprising at least two peaks between 1735 and 1705 cm−1 and a solubility of less than 20% wt. after 24 hours in porcine serum at 37° C., and in a second taxane solid form characterized by a vibrational spectrum comprising one peak between 1735 and 1705 cm−1 and a solubility of greater than 50% wt. after 24 hours in porcine serum at 37° C., wherein at least 10% of the taxane therapeutic agent is present in the first taxane solid form
positioning the coated implantable device within the body vessel;
and
radially expanding the coated implantable device within the body vessel so as to place the coated implantable device in contact with a portion of a wall of the body vessel in a manner effective to deliver at least a portion of the taxane therapeutic agent to the wall of the body vessel.

2 more elements

Dependencies are inferred from the claim text.

Taxane coatings for implantable medical devices

Life of this patent

Taxane coatings for implantable medical devices

Life of this patent

Abstract

Claims17