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US 8,137,450 B2Granted
Collagen-based lyophilised glue and the use thereof for producing an adhesive prosthesis
AssigneeSymatese
InventorsBernard Ragaru, Benjamin Herbage
Life of this patent
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Abstract
A lyophilized glue contains a collagen which is partially crosslinked with the aid of at least one type of aldehyde. A method for preparing the glue and the use thereof for producing an adhesive on anti-adhesive prosthesis are also provided.
Claims29
Glue for gluing two biological tissues together or for gluing a prosthesis onto a biological tissue, said glue comprising:
- a dry, solid lyophilized acidic mixture comprising:
- (i) collagen and a crosslinking agent comprising molecules with at least one aldehyde function, wherein said collagen in said mixture is incompletely crosslinked so that the aldehyde functions remain free to react in situ, or
- (ii) collagen modified to have aldehyde functions, wherein the modified collagen in said mixture is incompletely crosslinked so that the aldehyde functions remain free to react in situ, wherein said dry, solid lyophilized acidic mixture is effective as a glue for gluing two biological tissues together or for gluing a prosthesis onto a biological tissue.
Method for preparing an adhesive lyophilized prosthesis comprising the following steps:
- forming an acidic mixture a comprising:
- (i) collagen and a crosslinking agent comprising molecules with at least one aldehyde function, wherein said collagen in said mixture is incompletely crosslinked so that the aldehyde functions remain free to react in situ, or
- (ii) collagen modified to have aldehyde functions, wherein the modified collagen in said mixture is incompletely crosslinked so that the aldehyde functions remain free to react in situ;
- pouring the acidic mixture onto a prosthetic material;
- and
- lyophilizing the prosthetic material bearing the acidic mixture, thereby forming said adhesive prosthesis.
3 more elements
Dependencies are inferred from the claim text.