Recombinant parainfluenza virus expression systems and vaccines
AssigneeMedImmune, LLC
InventorsAurelia Haller, Kathleen Coelingh
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Abstract
The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
Claims4
An immunogenic composition comprising a chimeric Kansas-strain bovine parainfluenza virus type 3 (BPIV3), said chimeric BPIV3 comprising:
- (i) a Kansas-strain BPIV3 genome, and
- (ii) a heterologous sequence encoding an immunogenic epitope from a virus,
- wherein said heterologous sequence is inserted into said Kansas-strain BPIV3 genome at nucleotide position 5041, nucleotide position 8529, or within the hemagglutinin-neuraminidase glycoprotein gene.
An immunogenic composition comprising a chimeric Kansas-strain BPIV3, said chimeric BPIV3 comprising:
- (i) nucleotides 1-5041 and nucleotides 8529-15456 of a Kansas-strain BPIV3 genome;
- and
- (ii) a heterologous sequence encoding an immunogenic epitope from a virus.
Dependencies are inferred from the claim text.