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AssigneesArbor Vita Corporation, NoNO Inc.
InventorsMichael Tymianski, Jonathan David Garman
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The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
A method of delivering a pharmacologic agent to a subject, the method comprising:
A method of treating or effecting prophylaxis of a disease characterized by excitotoxicity comprising
In a method of delivering a pharmacologic agent linked to an internalization peptide to a subject, the improvement wherein the internalization peptide is administered with a mast cell degranulation inhibitor to inhibit mast cell degranulation inducible by the internalization peptide, wherein the pharmacological agent is a peptide having an amino acid sequence comprising ESDV (SEQ ID NO:12) or ETDV (SEQ ID NO:40) and the internalization peptide has an amino acid sequence comprising RKKRRQRRR (SEQ ID NO:51).
A method of delivering a pharmacologic agent to a subject the method comprising:
Dependencies are inferred from the claim text.