Method of identifying compounds using a transgenic pig model of cystic fibrosis
AssigneesUniversity of Iowa Research Foundation, The Curators of the University of Missouri
InventorsMichael J. Welsh, Christopher S. Rogers, Randall Prather, John Engelhardt, Ziying Yan
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Abstract
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.
Claims2
A method of identifying a therapeutic agent that can be used in the treatment of cystic fibrosis, the method comprising administering a candidate therapeutic agent to a transgenic pig whose genome has a homozygous disruption in a cystic fibrosis membrane transporter (CFTR) gene, wherein the pig has a symptom of cystic fibrosis, and monitoring the pig for a symptom of cystic fibrosis, wherein detection of improvement in a symptom of cystic fibrosis indicates the identification of a compound that can be used in the treatment of cystic fibrosis.
Dependencies are inferred from the claim text.