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AssigneesGenomidea Inc., AnGesMG, Inc.
InventorsHitoshi Kotani, Yasufumi Kaneda, Hirokazu Kawano, Masayuki Fukumura, Masayuki Kurooka
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The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.
A method for inhibiting tumor cell growth in an animal, comprising administering to said animal an effective amount of a composition consisting of a hemagglutinating virus of Japan envelope (HVJ-E) and a pharmaceutically acceptable carrier, wherein the composition is administered intratumorally.
Dependencies are inferred from the claim text.