Method for manufacturing gelatin with reduced endotoxin content and low endotoxin gelatin
AssigneeJellice Co., Ltd.
InventorsYoshitaka Kanayama, Yasuo Sakai
Life of this patent
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Abstract
A method of manufacturing gelatin with reduced endotoxin content. The method comprises processing a starting material gelatin-containing solution containing gelatin and an endotoxin with an ultrafiltration film having a molecular weight cut-off falling within a range of from 20,000 to 300,000 and having a molecular weight cut-off capable of passing at least a portion of the gelatin contained in the starting material gelatin-containing solution to obtain a permeate that is a gelatin-containing solution with a reduced endotoxin content. A gelatin having an average molecular weight falling within a range of 1,000 to 300,000 and an endotoxin content of less than 1 EU/mL per 1.0 percent of protein.
Claims9
A method of manufacturing gelatin with reduced endotoxin content, wherein the molecular weight of the liposaccharide subunits of the endotoxin is about 20,000 Da,
- comprising processing a starting material gelatin-containing solution containing gelatin,
- wherein the average molecular weight of said geletan contained in said starting material gelatin-containing solution is in a range of from 30,000 to 300,000 Da, and
- an endotoxin with an ultrafiltration membrane having a molecular weight cut-off falling within a range of from 50,000 to 300,000 Da and having a molecular weight cut-off capable of passing at least a portion of the gelatin contained in the starting material gelatin-containing solution to obtain a permeate that is a gelatin-containing solution with a reduced endotoxin content, wherein the gelatin concentration in said starting material gelatin-containing solution is in a range of 1 to 30 weight percent.
Dependencies are inferred from the claim text.