Indazolecarboxamide derivatives for the treatment and prevention of malaria

A method of treating malaria or inhibiting Plasmodium falciparum parasite in a patient in need thereof, which comprises administering to said patient an effective amount of a compound corresponding to general formula (I):

• in which:
• R1 represents a heteroaromatic group optionally substituted with one or two substituents chosen, independently of one another, from halogen atoms and heteroaromatic, C1-6 alkyl, —OH, —NH2, —NHR2, —NHCOR2, —COOR2, —CONH2, —CONHR2 and —CH2XR2 groups, where X is chosen from O, NH and S;
• Ar represents a heteroaromatic group optionally substituted with one or two substituents chosen, independently of one another, from halogen atoms and C1-6 alkyl, C1-6 thioalkyl, C1-6 alkoxy, —CH2OH, phenoxy, morpholinyl, —CH2-morpholinyl, —NH2, —NHR2, —NR2R3, —NHSO2R2, —CN, —SO2R2, —SO2NH2, —SO2NHR2, —COOH, —COOR2, —CONH2, —CONHNH2, —CONHR2, —CH2NHR2 and —CH2NR2R3 groups;
• R2 and R3, which may be identical to or different from one another, represent a C1-6 alkyl group optionally substituted with a —CONH2 group, with a phenyl group or with a heteroaromatic group;
• or else R2 and R3, which may be identical to or different from one another, represent a phenyl group or a heteroaromatic group;
• and
• n is equal to 0, 1, 2 or 3,
• or a pharmaceutically acceptable salt, hydrate or solvate thereof.