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US 7,763,112 B2Granted
Methods and systems for co-crystal synthesis
AssigneeTransform Pharmaceuticals, Inc.
InventorsJavier Gonzalez-Zugasti, Nathan Kane, Mark Oliveira, Matthew Peterson
Life of this patent
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Abstract
The present invention comprises methods and apparatuses for the production or formation of co-crystals. The methods and apparatuses can be used to grind two or more co-crystal components resulting in the formation of co-crystals. The resultant co-crystals can have several uses as disclosed herein.
Claims12
A method of producing co-crystals, comprising:
- (a) providing a mixture of co-crystal components to at least one well of a body, wherein said at least one well has a maximum diameter of between about 5.00 mm and about 15.00 mm;
- (b) providing at least one grinding ball to said at least one well of said body;
- (c) affixing a cover plate, that is substantially physically congruent to said body, to said body;
- (d) affixing said body to a shaking component;
- (e) selecting a vibration frequency and a vibration amplitude for said shaking component;
- and
- (f) vibrating said body, whereby said vibrating results in co-crystal formation.
4 more elements
A method of producing co-crystals, comprising:
- (a) providing a mixture of co-crystal components to at least one well of a body, wherein said at least one well has an end-to-end length of between about 1.00 cm and about 5.00 cm;
- (b) providing at least one grinding ball to said at least one well of said body;
- (c) affixing a cover plate, that is substantially physically congruent to said body, to said body;
- (d) affixing said body to a shaking component;
- (e) selecting a vibration frequency and a vibration amplitude for said shaking component;
- and
- (f) vibrating said body, whereby said vibrating results in co-crystal formation.
4 more elements
A method of producing co-crystals, comprising:
- (a) providing a mixture of co-crystal components to at least one well of a body;
- (b) providing at least one grinding ball to said at least one well of said body;
- (c) affixing a cover plate, that is substantially physically congruent to said body, to said body;
- (d) affixing said body to a shaking component;
- (e) selecting a vibration frequency and a vibration amplitude for said shaking component, wherein said vibration amplitude ranges from about 10.00 mm to about 100.00 mm;
- and
- (f) vibrating said body, whereby said vibrating results in co-crystal formation.
4 more elements
Dependencies are inferred from the claim text.