Multiplex data acquisition modes for ion mobility-mass spectrometry
AssigneesIonwerks, Inc., The Texas A&M University System
InventorsJohn A. McLean, David H. Russell, Thomas F. Egan, Michael V. Ugarov, J. Albert Schultz
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Abstract
A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
Claims56
A method for the acquisition of analytical data for a sample comprising the steps of:
- generating packets of gas-phase ions and neutral species from said sample;
- introducing said packets into a time dispersive ion mobility drift cell at a rate faster than the transient rate of separation of said ions by said drift cell;
- separating said ions in a first dimension according to their ion mobility;
- sampling the ions eluted by the ion mobility drift cell into a mass spectrometer;
- separating said ions in a second dimension in said mass spectrometer;
- detecting a mass spectrometric signal for the ions;
- and,
- processing said mass spectrometric signal using the ion packet injection frequency and an ion mobility-mass-to-charge correlation function.
A method for the acquisition of analytical data for a sample comprising the steps of:
- generating packets of gas-phase ions and neutral species from said sample;
- introducing said packets into a time dispersive ion mobility drift cell at a rate faster than the transient rate of separation of said ions by said drift cell;
- separating said ions in a first dimension according to their ion mobility;
- activating the ions as they elute from the ion mobility drift cell for dissociation into fragment ions;
- sampling the ions eluted by the ion mobility drift cell into a mass spectrometer;
- separating said ions in a second dimension in said mass spectrometer;
- detecting a mass spectrometric signal for the ions;
- and,
- processing said mass spectrometric signal using the ion packet injection frequency and an ion mobility-mass-to-charge correlation function.
Dependencies are inferred from the claim text.