Back to results
US 7,745,708 B2Granted
Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AssigneeNorthwestern University
InventorsSamuel I. Stupp, Jeffrey D. Hartgerink, Elia Beniash
Life of this patent
Estimating the term…
Abstract
Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
Claims16
A method of making a cylindrical micellar nanofiber composed of beta-sheets of peptide segment of peptide amphiphile comprising the steps of:
- (a) providing the peptide amphiphile molecule in an aqueous solution, wherein said peptide amphiphile molecule comprises a single C6 to C22 linear hydrocarbon segment covalently linked to a peptide segment comprising a bioactive epitope sequence selected from RGD, KGE, IKVAV (SEQ ID NO:
- 1) and YIGSR (SEQ ID NO:
- 20);
- and
- (b) contacting said peptide amphiphile molecule with an effective amount of a metal ion sufficient to induce formation of a cylindrical micellar nanofiber composed of beta-sheets.
2 more elements
Dependencies are inferred from the claim text.