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US 7,745,689 B2Granted
Nephropathy-associated gene
AssigneeAkari Inada
InventorsAkari Inada, Atsushi Fukatsu, Yutaka Seino
Life of this patent
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Abstract
A nephropathy-associated gene which encodes a transcription repressor; and a nonhuman transgenic animal suffering from nephropathy which is constructed by transferring the above gene and allows the observation of increases in urinary volume, urinary albumin and urinary NAG, pyelectasis, enlargement in kidney tubule and glomerular swelling at the early stage and the following sclerosis.
Claims4
A transgenic mouse comprising either 4 or 6 copies of transgenes encoding inducible cAMP early repressor Iγ (ICER Iγ) operably linked to a human insulin promoter;
- wherein the transgenic mouse develops nephropathy.
Dependencies are inferred from the claim text.