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AssigneeRiken
InventorsTakaomi Saido, Nobuhisa Iwata, Takashi Saito, Takahiro Suemoto, Jiro Takano
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The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid β peptide (Aβ) or a living part thereof, characterized in that Aβ42/Aβ40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof.
A transgenic mouse or living part thereof comprising a chimeric APP gene encoding a human Aβ having a FAD mutation and differing from the human APP gene of SEQ ID NO:
A knock-in mouse or living part thereof comprising a chimeric APP gene that encodes human Aβ having a Swedish mutation and differs from the human APP gene of SEQ ID NO:
Dependencies are inferred from the claim text.