Back to results
US 7,745,657 B2Granted
D-homoandrosta-17-yl carbamate derivatives as selective glucocorticoid receptor ligands
AssigneeMerck Sharp & Dohme Corp.
InventorsAmjad Ali, Mark L. Greenlee, Carol A. McVean, Robert S. Meissner, Gayle E. Taylor
Life of this patent
Estimating the term…
Abstract
The present invention is directed to D-homoandrosta-17-yl-carbamate derivatives as selective glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
Claims11
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein
- R1 and R2 are independently selected from the group consisting of:
- Ra, —C(O)—Ra, and —C(O)—N(Ra)Ra;
- R3 and R4 are independently selected from the group consisting of:
- hydrogen, C1-10alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, aryl, heteroaryl, heterocyclyl, and C1-10fluoroalkyl;
- and
- each Ra is independently selected from the group consisting of:
- hydrogen, C1-10alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, aryl, heteroaryl, heterocyclyl, and C1-10fluoroalkyl.
5 more elements
Dependencies are inferred from the claim text.