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US 7,745,637 B2Granted
Peptide deformylase inhibitors
AssigneeGlaxoSmithKline LLC
InventorsKelly M. Aubart, Ajita Bhat, Sigfried B. Christensen, IV, Jack D. Leber, Xiangmin Liao
Life of this patent
Estimating the term…
Abstract
Novel PDF inhibitors and novel methods for their use are provided.
Claims4
A compound according to Formula (I):
- wherein
- R1 is selected from the group consisting of C1-C9alkyl, C1-2alkylAr, and Ar;
- R2 is selected from the group consisting of hydrogen, C1-C9alkyl, C1-4alkylAr′, NHR4, NHC(O)R4, C2-4alkylNR3R4, C1-3alkylC(O)NR3R4, C1-3alkylC(O)Ar′, C2-3alkylNHC(O)NR3R4, C2-3alkylNHC(O)Ar′, and C1-2alkylSO2R4;
- R3 is selected from the group consisting of C1-C9alkyl, C1-2alkylAr, and Ar;
- R4 is R3, Ar′, or R4 may be taken together with R3 and the nitrogen atom to which they are attached to form a heterocyclic ring which is optionally substituted with one, two, or three substituents each independently selected from the group consisting of C1-3alkyl, aryl, C1-3alkoxy (optionally substituted by one to three F), aryloxy, carboxy, oxo, hydroxy, amino, nitro, and cyano, or which may be optionally fused to an aryl, a heteroaryl, or a second heterocyclic ring;
- Ar is selected from the group consisting of phenyl, furyl, and thienyl, all of which can be optionally substituted with one, two, or three substituents each independently selected from the group consisting of:
- C1-C3alkyl, CN, F, Cl, Br, and I;
- and
- Ar′ is selected from the group consisting of:
- naphthyl, furyl, pyridyl, thienyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, benzofuranyl, indolyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, pyrrolyl, and pyrimidyl, all of which can be optionally substituted with one, two, or three substituents each independently selected from the group consisting of:
- C1-C6alkyl, C1-C6alkoxy, (CH2)0-5CO2R1, C(O)N(R1)2, CN, (CH2)0-5OH, NO2, F, Cl, Br, I, CF3, N(R1)2, and NHC(O)R1;
- or a pharmaceutically acceptable salt thereof.
9 more elements
A compound selected from the group consisting of:
- N-[(S)-2,5-Dioxo-4-pentyl-1-phenyl-imidazolidin-4-ylmethyl]-N-hydroxyformamide;
- N-[(S)-1-Biphenyl-4-ylmethyl-4-butyl-2,5-dioxo-imidazolidin-4-ylmethyl]-N-hydroxyformamide;
- N-{(S)-4-Butyl-1-[2-(5-chloro-3-methyl-1-benzo[b]thiophen-2-yl)-2-oxo-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-N-hydroxyformamide;
- and
- 2-{(S)-4-Butyl-4-[(formyl-hydroxy-amino)methyl]-2,5-dioxo- imidazolidin-1-yl}-N-(3,5-dichlorophenyl)acetamide;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.