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US 7,745,631 B2Granted
Process for producing 2-(phenyl methyl thio)-3-pyridine carboxylic acid
AssigneeJubilant Organosys Limited
InventorsShailendra Kumar Singh, Ashutosh Agarwal
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Abstract
The invention discloses an improved process for producing an intermediate to produce large quantity of 2-(Phenyl methyl thio)-3-pyridine carboxylic acid. The process comprises reacting 2-chloro-3-cyanopyridine with benzyl mercaptan in presence of a base and an aprotic solvent. The resulting intermediate 2-(phenyl methyl thio)-3-cyanopyridine is hydrolyzed in presence of a base in an autoclave and isolated under acidic condition to get the desired product.
Claims20
A process for producing 2-(Phenyl methyl thio)-3-pyridine carboxylic acid, consisting essentially of:
- reacting 2-chloro-3-cyanopyridine with benzyl mercaptan in the presence of a base and an aprotic solvent;
- separating inorganic cake by filtration;
- recovering the aprotic solvent to obtain an intermediate;
- hydrolyzing resulting intermediate in the presence of a base in autoclave;
- isolating the resultant under acidic conditions followed by washing and drying to produce 2-(Phenyl methyl thio)-3-pyridine carboxylic acid.
2 more elements
Dependencies are inferred from the claim text.