Back to results
US 7,745,630 B2Granted
Triazolyl piperidine arginine vasopressin receptor modulators
OwnerJustin Stephen Bryans, Patrick Stephen Johnson +2inventors
InventorsJustin Stephen Bryans, Patrick Stephen Johnson, Lee Richard Roberts, Thomas Ryckmans
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Z, O, A, V, Y and Y′ are as defined herein; are useful for treating dysmenorreah.
Claims15
A compound of formula (I),
- or a pharmaceutically acceptable salt thereof, wherein:
- X is —[CH2]a—R or —[CH2]a—O—[CH2]b—R;
- a is 1;
- b is a number selected from 0 to 4;
- R is H, CF3 or Het;
- Het is imidazolyl or triazolyl;
- Y is one to three substituents independently selected from H, halo, CN, C1-6 alkyl, C1-6 alkoxy, wherein said C1-6 alkyl is unbranched and is optionally substituted on its terminal carbon atom with one to three fluoro or one pyrrolidinyl and wherein said C1-6 alkoxy is unbranched and is optionally substituted on its terminal carbon atom with one to three fluoro;
- V is a direct bond;
- Ring A is a piperidine ring, wherein said piperidine ring is optionally substituted with one to three groups selected from C1-6 alkyl, phenyl or hydroxy;
- Q is a direct bond;
- Z is selected from the group consisting of phenyl, pyridyl, quinolinyl, isoquinolinyl, naphthyl, benzoimidazolyl, benzotriazolyl, oxadiazolyl, indazolyl and indolyl, each optionally substituted with one to three groups selected from W;
- W independently at each occurrence is halo, hydroxy, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylSO2, C1-6 alkylSO, C1-6 alkylS, C3-6 cycloalkoxy, C3-6 cycloalkyl, phenyl, phenoxy, pyridinyl, pyrimidinyl, benzyl, benzyloxy or H2NSO2, wherein said C1-6 alkyl or said C1-6 alkoxy are each unbranched and are each optionally substituted on the terminal carbon atom with one to three fluoro.
9 more elements
{4-[4-(4-Chloro-phenyl)-5-[1,2,3]triazol-2-ylmethyl-4H-[1,2,4]triazol-3-yl]-piperidin-1-yl}-(3,5-difluoro-phenyl)-methanone, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.