Stereoselective alkylation of chiral 2-methyl-4-protected piperazines

A process to prepare a compound of Formula XIV,

• where G is selected from the group consisting of alkyl, halogenated alkyl, alkoxy, aryl aryloxy and arylalkoxy,
• by reacting a compound of Formula XI,
• where Y is selected from the group consisting of alkyl, halogenated alkyl, or aryl with said aryl being optionally substituted with alkyl, nitro or halogen,
• with a compound of Formula X,
• in the presence of an inorganic catalyst in a solvent, wherein said compound of Formula XIV forms in at (east 50% yields with at least about a 2:1 ratio of R,S stereochemistry to S,S stereochemistry respectively.