Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions
AssigneeApotex Pharma Chem Inc.
InventorsAllan W. Rey, Lotfi Derdour, K.S. Keshava Murthy, Probal Kanti Datta, Martin Ehlert, Stephen E. Home
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Abstract
A process for the preparation of an acid addition salt of ziprasidone base and intermediates thereof comprising exposing the ziprasidone base in solid form to a gaseous acid in a substantially dry environment.
Claims79
A process for the preparation of an acid addition salt of ziprasidone base comprising reacting ziprasidone base in solid form with gaseous acid in a substantially dry environment thereby forming the acid addition salt of ziprasidone base, wherein the process is substantially solvent free.
A process for the preparation of an acid addition salt of ziprasidone base comprising reacting ziprasidone base in solid form with gaseous acid, at a temperature in the range of from about −50° C. to about 40° C., in a substantially dry environment and agitating the ziprasidone base in solid form, thereby forming the acid addition salt of ziprasidone base, wherein the process is substantially solvent free.
Dependencies are inferred from the claim text.