Long acting bronchodilators for the treatment of respiratory diseases

A compound of formula 1

• wherein
• n denotes 1 or 2;
• A denotes O, N or a single bond;
• B denotes —CH2—O—;
• L denotes a double-bonded group selected from among
• —CO—(CH2)m—, —CO—(CH2)m—NH—CO—(CH2)o—, —CO—(CH2)m—CO—NH—(CH2)o—,
• —CO—(CH2)m—O—(CH2)p—, —(CH2)p—, —(CH2)p—O—(CH2)r—, —(CH2)2—NH—CO—(CH2)o—
• m, o independently of one another denote 1 to 8;
• p, r independently of one another denote 2 to 8;
• R1, R2, R3 which may be identical or different, denote hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, phenyl, benzyl, —COOH, —COOmethyl, —O—CH2—COOH, —O—CH2—COOmethyl, —O—CH2—COOethyl, —O—CH2—CH2—COOH, —O—CH2—CH2—COOmethyl, —O—CH2—CH2—COOethyl, CN, NO2, fluorine, chlorine or bromine;
• D denotes a double-bonded group selected from among
• —CH2—CH2— and —CH═CH—;
• R4 denotes hydrogen, methyl, ethyl, phenyl, benzyl or the group
• E denotes a group selected from among
• R5 denotes hydrogen, hydroxy, methyl, ethyl, methyloxy, ethyloxy, —CF3, HO—CH2, HO—CH2—CH2 or fluorine;
• M and Q which may be identical or different, preferably identical, denote —S or —CH═CH—;
• R6, R7, R6′ and R7′, which may be identical or different, denote hydrogen, methyl, methyloxy, —CF3 or fluorine;
• Rx and Rx′ which may be identical or different denote hydrogen, methyl, methyloxy, —CF3 or fluorine
• or
• Rx and Rx′ together denote a single bond or the bridging group —O—, optionally in the form of the individual enantiomers or optionally diastereomers, mixtures of the individual enantiomers or optionally diastereomers or racemates, optionally in the form of the acid addition salts thereof with pharmacologically acceptable acids.