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US 7,745,598 B2Granted
CpG single strand deoxynucleotides for use as adjuvant
AssigneeChangchun Huapu Biotechnology Co., Ltd.
InventorsLiying Wang, Musheng Bao, Yongli Yu
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Abstract
The present invention provides an adjuvant, which includes at least one single strand deoxynucleotide containing a CpG dinucleotide. The single strand deoxynucleotide comprises one or more CpG dinucleotides. When used in combination with rabies vaccine, HBV vaccine or other vaccines, the adjuvant can significantly improve the immune effect of the vaccine.
Claims8
A method of improving immunogenicity of a vaccine, comprising coadministering said vaccine to a subject with a single strand deoxynucleotide, comprising the nucleotide sequence of SEQ ID NO:
- 167 and said vaccine.
Dependencies are inferred from the claim text.