TRPC6 involved in glomerulonephritis

A method of identifying a subject with Focal and Segmental Glomerulosclerosis (FSGS), comprising:

• analyzing the nucleotide sequence of a Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRCP6) gene in a nucleic acid sample obtained from the subject;
• comparing the nucleotide sequence of the sample gene to the nucleotide sequence of a reference wild-type-TRPC6 gene comprising SEQ ID NO:
• 64 to determine one or more differences between the nucleotide sequence of the sample gene and the reference gene;
• and
• identifying the subject as having FSGS if the sequence of the gene of the subject differs from the reference gene at position 335 of the coding sequence of the reference gene, or identifying the subject as not having FSGS if the sequence of the gene of the subject does not differ from the reference gene at position 335 of the coding sequence.

A method of identifying a subject at increased risk of developing Focal and Segmental Glomerulosclerosis (FSGS), comprising:

• analyzing the nucleotide sequence of a Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) gene in a nucleic acid sample obtained from the subject;
• comparing the nucleotide sequence of the sample gene to the nucleotide sequence of SEQ ID NO:
• 64 to determine one or more differences between the nucleotide sequence of the sample gene and SEQ ID NO:
• 64;
• and
• identifying the subject as being at increased risk of developing FSGS if the sequence of the gene of the subject differs from SEQ ID NO:
• 64 leotide position 335 of the coding sequence, or identifying the subject as being at no increased risk if the sequence of the gene of the subject does not differ from SEQ ID NO:
• 64 at nucleotide position 335 of the coding sequence.