Human E3α ubiquitin ligase family

An isolated antibody or fragment thereof that specifically binds the polypeptide comprising the amino acid sequence selected from the group consisting of:

• (a) the amino acid sequence set forth in SEQ ID NO:
• 2;
• (b) an amino acid sequence that is at least 95 percent identical to the amino acid sequence of SEQ ID NO:
• 2, wherein the polypeptide has the E3α ubiquitin ligase activity of the polypeptide set forth in SEQ ID NO:
• 2;
• and
• (c) the amino acid sequence set forth in SEQ ID NO:
• 2 with 1 to about 100 conservative amino acid substitution(s), wherein the polypeptide has the E3α ubiquitin ligase activity of the polypeptide set forth in SEQ ID NO:
• 2.