Antibodies to sulfated carbohydrates
AssigneeCalifornia Institute of Technology
InventorsSarah E. Tully, Linda Hsieh-Wilson
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Abstract
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to chondroitin sulfate, particularly CS-A, CS-C and CS-E tetrasaccharides. The present invention also relates to methods of making anti-CS antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment.
Claims9
An isolated antibody comprising a heavy chain and a light chain, wherein said heavy chain comprises the three heavy chain complementarity determining regions (CDRs) of antibody 2D11-2A10 that is produced by a cell line deposited under ATCC accession number PTA10049, and wherein said light chain comprises the three light chain CDRs of said antibody 2D11-2A10, wherein the isolated antibody binds to a mammalian chondroitin sulfate E oligosaccharide comprising one or more disaccharides in the following structure:
- wherein n is greater than 0.
Dependencies are inferred from the claim text.