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US 7,745,581 B2Granted
T-bet compositions and methods of use thereof
AssigneePresident and Fellows of Harvard College
InventorsLaurie H. Glimcher, Susanne J. Szabo
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AssigneePresident and Fellows of Harvard College
InventorsLaurie H. Glimcher, Susanne J. Szabo
Estimating the term…
Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:4.
An isolated polypeptide comprising an amino acid sequence which has at least 90% amino acid identity to the full length amino acid sequence of SEQ ID NO:2 wherein the polypeptide binds a consensus T-box site in DNA and induces IFN-γ production in CD4+ cells.
An isolated polypeptide comprising an amino acid sequence which has at least 90% amino acid identity to the full length amino acid sequence of SEQ ID NO:4 wherein the polypeptide binds a consensus T-box site in DNA and induces IFN-γ production in CD4+ cells.
An isolated polypeptide comprising the amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO:1.
An isolated polypeptide comprising the amino acid sequence encoded by the nucleic acid sequence of SEQ TD NO:3.
An isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which has at least 90% nucleotide identity with SEQ ID NO:1 over its full length, and encodes a polypeptide that binds a consensus T-box site in DNA and induces IFN-γ production in CD4+ cells.
An isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which has at least 90% nucleotide identity with SEQ ID NO:3 over its full length, and encodes a polypeptide that binds a consensus T-box site in DNA and induces IFN-γ production in CD4+ cells.
An isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence comprising at least 700 contiguous nucleotides of SEQ ID NO:1 which sequence encodes a polypeptide that binds a consensus T-box domain and induces IFN-γ production in CD4+ cells.
An isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence comprising at least 600 contiguous nucleotides of SEQ ID NO:3 which sequence encodes a polypeptide that binds a consensus T-box domain and induces IFN-γ production in CD4+ cells.
Dependencies are inferred from the claim text.