Inhibitor of NF-KB activation
OwnerDavid Wallach, Andrei Kovalenko +1inventors
InventorsDavid Wallach, Andrei Kovalenko, Giuseppina Cantarella
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Abstract
The present invention relates to a protein, designated NAP (Nemo Associated Protein), that was discovered to inhibit the activation of transcription factor NF-kB by various signals that are important in inflammatory and immune processes. The DNA and the recombinant production of this protein is also disclosed as well as methods of using the protein or encoding DNA.
Claims17
An isolated protein which is capable of binding to tumor necrosis factor receptor-associated 2 protein (TRAF2), said protein comprising:
- (A) a polypeptide of SEQ ID NO:3;
- or
- (B) a variant that has no more than ten amino acid changes from the amino acid sequence of SEQ ID NO:3, wherein said variant is capable of binding to TRAF2.
A molecule having the binding portion of an antibody capable of binding to the polypeptide of SEQ ID NO:3.
An isolated protein comprising:
- A) a polypeptide of SEQ ID NO:
- 3;
- or
- B) a variant that has no more than 10 amino acid changes from the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.