Compounds that bind to P185 and methods of using the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsMark I. Greene, Ramachandran Murali, Alan Berezov
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Abstract
Novel peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic agents. are disclosed. Method of detecting tumors that have p185 on tumor cell surfaces are disclosed. Methods of preventing transformation of a normal cell into a tumor cell in an individual at risk of developing a tumor having tumor cells which have p185 on their surfaces are disclosed. Methods of treating an individual who has cancer characterized by tumor cells that have a p185 on their cell surfaces are disclosed.
Claims5
An isolated cyclic peptide having an amino acid sequence selected from the group consisting essentially of:
- YCDGFYACYMDV-NH2 (SEQ ID NO:
- 113 wherein the carboxy terminus is amidated);
- FCDGFYACYMDVK-NH2 (SEQ ID NO:
- 123 wherein the carboxy terminus is amidated);
- and
- GFCDGFYACYMDV-OH (SEQ ID NO:
- 134 wherein the carboxy terminus is hydroxylated).
Dependencies are inferred from the claim text.