US 7,745,574 B2 · Compounds that regulate apoptosis

Abstract

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.

Claims13

Dependent claims

A compound comprising:

a peptide consisting of the sequence of SEQ ID NO:60 or mutation or fragment thereof, wherein the peptide is pro-apoptotic;
and
a cell-penetrating-peptide, wherein said compound induces apoptosis of mammalian cells expressing Bcl-2 or Bcl-2 related proteins.

Dependencies are inferred from the claim text.

Facts

Application

11/433,783Filed 11 May 2006 · us provisional application

Priority

12 May 2005

Published

US 2007/0054863 A18 Mar 2007

Granted

29 Jun 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

G01N 33/6872
Involving proteins, peptides or amino acids: intracellular protein regulatory factors and their receptors, e.g. including ion channels
A61P 35/00
Antineoplastic agents
C07K 14/4747
Not used: apoptosis related proteins
C07K 14/70567
Receptors; Cell surface antigens; Cell surface determinants: nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

Compounds that regulate apoptosis

Life of this patent

Compounds that regulate apoptosis

Life of this patent

Abstract

Claims13